Movers and shakers: cell cytoskeleton in cancer metastasis

Movers and Shakers

Most projects, in most walks of life, require the participation of multiple parties. While it is difficult to unite people in a common endeavor, some people, whom we call “movers and shakers,” seem able to do it. The paper specifically examines moving and shaking of an investment project. We analyze a model with a large number of ex ante identical agents. Agents form social connections, bid to ...

Movers and Shakers: Conversation and conflict in a serious game for tablets

Movers and Shakers is a tablet-based serious game that explores how subversive game design can foster meaningful conversational conflict beyond outside the game’s digital screens. This twoplayer strategy puzzle was developed at the Singapore-MIT GAMBIT Game Lab and is used as a research tool to explore novel challenges in multiplayer serious games. The project provides insights into the afforda...

Ovarian Metastasis in Endometriod Type Endometrial Cancer

A Review of the Function of Circulating Cell Free miRNAs as Promising Biomarkers in Cancer Diagnosis, Treatment, and Metastasis

Cell Free miRNAs are small, non-coding molecules that can be secreted into the bloodstream in very stable forms. These types of miRNAs, like intracellular miRNAs, participate in the control of many biological processes and are expressed in both natural and pathological conditions. Quantitative and qualitative changes in expression of circulating miRNAs are associated with the onset and progress...

The Role of Matrix Metalloproteinase-3 Functional 5A/6A Promoter Polymorphism in Tumor Cell Progression and Metastasis of Breast Cancer

In the human genome, chromosome 11 contains a cluster of matrix metalloproteinase (MMP) genes. Single nucleotide polymorphisms in the promoter region of MMP genes are important for MMP expression. A common adenine deletion polymorphism (5A) at position -1171 of the MMP-3 gene promoter (5´-AAAAAACCAT-3´ change to 5´-AAAAACCAT-3´) facilitates transcriptional factor binding and MMP-3 promoter acti...